New Milbemycins from Streptomyces hygroscopicus subsp. aureolacrimosus. Fermentation, Isolation and Structure Elucidation.
نویسندگان
چکیده
منابع مشابه
Milbemycins, a new family of macrolide antibiotics. Fermentation, isolation and physico-chemical properties of milbemycins D, E, F, G, and H.
Strain Au-3, a mutant of Streptomyces hygroscopicus subsp. aureolacrimosus, obtained with ultraviolet irradiation, was a high-yield strain of milbemycins D, E, F, G and H. Fermentation studies on the strains were conducted in shake flasks and 30-liter jar fermentors. Isolation of the metabolites was performed by adsorption on resinous adsorbent followed by elution with aqueous MeOH and separate...
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Milbemycins are a family of sixteen-membered macrolides produced by Streptomyces hygroscopicus subsp. aureolacrimosus. They exhibit broadspectrum insecticidal and acaricidal activity. * ~ 3) In the course of our studies on the microbial conversion of milbemycins, we obtained 13/?hydroxymilbemycins A3 (2b), A4 (lb), and D (3b) from milbemycins A3 (2a), A4 (la), and D (3a), respectively, and 1 3j...
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Ten novel alpha and beta class milbemycins have been isolated and characterized from the Streptomyces sp. E225, which has previously been shown to produce four related milbemycins. Some of the metabolites contain new structural features including, VM48641 which possesses an alpha-methoxyl substituent at C-27, and VM48642 which contains a furan ring at the terminus of the C-26 side chain. Severa...
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Here, we report the draft genome sequence of strain NBRC 16556, deposited as Streptomyces hygroscopicus subsp. hygroscopicus into the NBRC culture collection. An average nucleotide identity analysis confirmed that the taxonomic identification is correct. The genome sequence will serve as a valuable reference for genome mining to search new secondary metabolites.
متن کاملMicrobial conversion of milbemycins: 28-hydroxylation of milbemycins by Amycolata autotrophica.
Milbemycins are a family of sixteen-membered macrolides produced by Streptomyces hygroscopicus subsp. aureolacrimosus. They exhibit broad-spectrum insecticidal and acaricidal activity. * ~ 3) In the course of our studies on the microbial conversion of milbemycins, we obtained 13/?hydroxymilbemycins A4, A3, D, 13/Miydroxy-LLF28249a, 28-hydroxymilbemycin D, and 28-hydroxy-LL-F28249a by using Cunn...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 2000
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.53.694